Ovivo Building Mode by Masters Media. Live application coming soon.
Ovivo · Governed, scored evidence

As close to the truth as the evidence allows.

No one — no clinician, no committee — can hold an evidence base that grows by thousands of papers a day. So Ovivo AI reads it continuously, debating and scoring the world's biomedical literature so every conclusion shows how settled the science is, how certain it is, and where it came from. The best the evidence allows, in service of the best care for each patient.

Human-governed De-identified data Not a medical device
40M+
biomedical papers, de-duplicated & integrity-scored
1,000s
new papers ingested every day
~Minutes
from publication to updated synthesis
Glimpse inside

Watch Ovivo AI debate, live.

A window straight into Ovivo AI, our autonomous evidence engine. You can watch the debate; you can't influence it, and that's the point. Showing the most active discussions, refreshing every few seconds.

Live Auto-refreshing every 3s · most active debates Illustrative preview · not live engine output read-only · you can't influence it
Showing the 6 most active of 15 live debates Research use only · not medical advice
An illustrative view of how the engine will run a living review and work with Ovivo AI directly.
The problem

Evidence ages the moment it's written.

A systematic review is a photograph: accurate the day it's published, and quietly out of date ever after. The gap between what the evidence shows and what reaches a clinician is still measured in years, so decisions get made on a version of the truth that has already moved on. Ovivo AI updates its synthesis within minutes of a paper publishing, and compresses the governed path to the clinician from years to days.

Today · in vitro

Static synthesis

frozen in glass

Conventional tools answer the question you asked, at the moment you asked it. The output is a snapshot that begins to decay immediately.

  • Re-run manually to catch new trials
  • Reviews stale before they're cited
  • No memory of what changed, or when
Ovivo · in vivo

Living synthesis

in the living system

Ovivo AI keeps reasoning after you close the tab. Each document is a living artefact that re-synthesises itself against new evidence as it arrives.

  • Continuously current, no re-prompting
  • Notifies you only when conclusions move
  • Full provenance: every change traced
Rigour

The most rigorous evidence, kept current.

Currency is worthless without trust. A synthesis you can't defend to a committee, reviewer, or regulator is a liability, so every conclusion carries its certainty, its dissent, and its provenance. Speed keeps rigour sustainable; it doesn't replace it.

Certainty, graded

GRADE certainty (high to very low), risk of bias (RoB 2, ROBINS-I), heterogeneity (I²), publication-bias diagnostics, and trial-registry linkage that catches outcome-switching and the file-drawer problem. Attached to every conclusion, not buried.

Disagreement, surfaced

The full distribution of findings (conflicting trials, effect sizes, confidence intervals) instead of a single smoothed answer where the field splits, with explicit flags on who was studied and where the evidence may not transfer.

Integrity & retractions

When a paper is retracted, corrected, or flagged for integrity, the change propagates backward through every conclusion that relied on it, and you're notified.

Reproducible method

Search strategy, inclusion and exclusion with reasons, and conflict resolution, exposed and exportable: PRISMA flow, pre-registered protocol, full audit trail.

And it stays citable: any living document can be frozen as an immutable, versioned snapshot you can reference in a paper, and observational signal is never laundered into a causal claim.
How it works

Ovivo AI never stops reading.

Where a static tool waits for your prompt, Ovivo AI runs continuously against active evidence streams and patches the document the moment something changes. Teams work in shared, governed, versioned workspaces.

01

Watch

Ovivo AI monitors journals, preprints, trial registries, and approved institutional datasets in real time.

02

Synthesise

New signal is appraised, weighed against the existing body, and reconciled into the current evidence picture.

03

Patch

The living document rewrites the affected sections, preserving a full, reviewable history of what changed and why.

04

Notify

If a conclusion shifts, the right people are told, and downstream guidelines can be flagged for review.

Who it's for

Built for the people who produce evidence.

Ovivo Research is licensed to the institutions at the source of medical knowledge, the bodies that turn it into practice, and the agencies that decide what gets funded.

Universities & research groups

Departments & systematic-review teams

Keep every literature review and living systematic review current across a project's lifetime, instead of re-screening from scratch each grant cycle.

Research hospitals

Clinical research units

Synthesise published literature alongside consented, de-identified real-world data to see what is actually happening, sooner.

Guideline bodies

Councils & committees

Receive drafted, evidence-linked updates the moment the underlying research moves, ready for committee review and ratification.

HTA, payers & public health

Assessment, reimbursement & policy bodies

Base coverage, cost-effectiveness, and policy decisions on an evidence base that updates as trials report, not on a dossier frozen at submission.

Trust & governance

Living, but never unsupervised.

  • De-identified data only

    This layer operates on aggregated, IRB-approved datasets. Identifiable patient data is structurally walled off and never enters it.

  • Human ratification

    Ovivo proposes; people decide. Evidence updates are drafted for review; committees and clinicians stay the decision-makers.

  • Full auditability

    Every synthesis is traceable to source and every revision is logged. A living conclusion is also a defensible one.

"The speed comes from compressing synthesis and drafting from months to hours. The committee still governs."

Ovivo governance principle

Get in touch

Put the best current evidence to work.

We're building Ovivo Research for universities, research hospitals, and guideline bodies who want continuous evidence synthesis in practice. Tell us about your work.